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Abstract #3929

Increased Growth with Eccentricity: 4D Flow Evaluation of Valve-Related Aortic Disease

S. Jarrett Wrenn1, Monica Sigovan1, Michael Hope1

1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Bicuspid aortic valve is a relatively common congenital anomaly and is associated with ascending aortic aneurysm. 4D Flow MRI has previously demonstrated unique systolic flow patterns in bicuspid valve patients. Here we examined ascending aorta growth rates in patients with bicuspid aortic valves and in tricuspid aortic valve controls, who were all studied with 4D Flow MRI. Abnormal flow patterns, assessed both qualitatively and quantitatively, correlated with more rapid ascending aortic growth. This suggests that 4D Flow MRI could be used to risk stratify bicuspid aortic valve patients with regards to the development of ascending aortic aneurysm.

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Keywords

abnormal addressed aging aorta aortic arrow ascending bicuspid biomedical blood causality common congenital contrast control controls correlated correlation course debated degree demo develop dimensions directly disc disease eccentric eccentricity enlarged evaluating exact examined flow furthermore good graded grow growth helical highlighted hope identify interval investigate larger mark marked markedly maxim maximally measured measures meters mined pacts patients peak placement previously quantitative rapid recently reflects regression related reported required reviewed risk serial shear sign since stable stream stress studies suited systolic underlying valve vessel wall ween woman year years