Meeting Banner
Abstract #3919

Cerebral Cine PC-MRI to Investigate Brain Hemodynamic of Neonates with Transposition of the Great Arteries Before and After Cardiopulmonary Bypass Surgery.

Malek I. Makki1, Olivier Baledent2, Hitendu Dave3, Walter Knirsch4, Bea Latal5, Ianina Scheer6, Cornelia Hagmann7

1MRI Research Center, University Chidlren Hospital, Zurich, Switzerland; 2Imagerie Medicale, CHU Nord Amiens, France; 3Congenital Cardiovascular Surgery, University Children Hospital Zurich; 4Cardiology, University Children Hospital Zurich; 5Child Development, University Children Hospital Zurich; 6Diagnostic Imaging, University Children Hospital - Zurich; 7Neonatalogy, University Hospital Zurich

We applied 2D cine PC-MRI to investigate brain hemodynamic of 4 term neonates with TGA before and after CPB surgery along with 4 age-matched healthy neonates. Flows were bilaterally measured in the internal carotid, vertebral arteries and jugular veins and we combined left and right measures. We observed striking differences in the shape and peak values of the pre-surgical group compared to healthy controls both in systolic and diastolic period. We also reported significant changes in the arterio-venous flows of these patients following CPB surgery where the peak values at both systole and diastole resembled that of healthy controls.

Abstract PDF E-Poster Video

Keywords

ability additional altered although amplitudes anesthesiologist arrow arterial arteries artery automatic balloon bilaterally birth blood born brain bypass capability cardiac cardiology cardiopulmonary carotid caudal cerebral challenges child children cine circulation clinicians combined congenital control controls corner cranial curve curves cycle days decreased development diastole diastolic diseases displayed evaluate even extraction fast flow flows gating gestation graph great growing healthy heart help hemispheric hospital impact in vivo index infarctions infusion injury internal invest investigate irregular jugular known lasts lesions life matched measured measures miller natural negative neither neonatal neonate neonates normalized numerous open paired patient patients peak period peripheral positive post postnatal processing quantify recruited redistribution reliable repetitions repetitive represent reproducible require resembled resolution revealed segment selected semi severe severity shape shapes side significantly sleep slice smooth snapshot software spatial subjects successfully surgeons surgery surgical systole systolic term third thresholding transposition undergoing upper vascular veins velocity venous vertebra vertebral vessel vessels views week weeks