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Abstract #3890

Steady-State First-Pass Perfusion (SSFPP): A 3D "TWIST" in Myocardial First-Pass Perfusion Imaging

Shivraman Giri1, Hui Xue2, Abdul Wattar1, Yu Ding1, Randall Kroeker3, Gerhard Laub4, Peter Kellman5, Sven Zuehlsdorff6, Subha V. Raman1, Orlando P. Simonett

1The Ohio State University, Columbus, OH, United States; 2Siemens Corporate Research, Princeton, NJ, United States; 3Siemens Healthcare, Winnipeg, Manitoba, Canada; 4Siemens Healthcare, San Francisco, CA, United States; 5National Institutes of Health, Bethesda, MD, United States; 6Siemens Healthcare, Chicago, Il, United States

We present a new approach to 3D myocardial first-pass perfusion imaging. The technique uses EKG-gated SSFP sequence such that data is acquired only during mid-diastole, whereas the magnetization is maintained in steady-state at other times. TWIST acquisition scheme is combined with GRAPPA to achieve the desired acceleration; the dynamic 3D frames were then motion-corrected using 3D non-rigid registration. Finally, pixel-wise contrast enhancement ratio (CER) images were generated to improve visualization.

Keywords

acceleration achieved acquisition additional address agent almost alternative artifacts assessment automated automatic avoids bandwidth beats become blood bolus borders bright capture causes central cine circulation circumvents clinical cohort combination computed constant contouring contrast correction correlation curves dead defects defined depicts despite detecting develop diagnostic dimensional ding dynamics efficiency elimination enabling enhance enhanced evaluate every exhibits facilitates feasibility footprint frame furthermore future gadolinium gated giving health healthy heart hold initial institutes insufficient intensity intrinsic kinetics larger late leaving limitations linear long materials matrix minutes mitigating modulation motion myocardial myocardium national nearly optimized partial pass pathologic patient perfusion peripheral pixel plotted poor potentially preparation primarily prior product profile propose proposed quality recovery reduce reducing regional relying remain remote rendered report reporting resolution resting rigid ringing saturation scanner schemes serendipitously slab slice space steady step stress studies subjects subsequently sufficiently suspected technological temporal theory tissue trial twist undiagnosed updated varied varying volunteers wash whereas