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Abstract #3825

Atherosclerotic Plaque Imaging with Integrated PET/MR: Preliminary Results in a Rabbit Model

Isabel Dregely1, Christine Baumgartner2, Eliane Weidl1, Stephan G. Nekolla1, Carl Ganter3, Jaroslav Pelisek4, Markus Schwaiger1, Iina Laitinen1

1Department of Nuclear Medicine, Klinikum rechts der Isar der TU Mnchen, Munich, Bavaria, Germany; 2Centre of Preclinical Research, Klinikum rechts der Isar der TU Mnchen, Munich, Bavaria, Germany; 3Department of Radiology, Klinikum rechts der Isar der TU Mnchen, Munich, Bavaria, Germany; 4Clinic for Vascular Surgery, Klinikum rechts der Isar der TU Mnchen, Munich, Bavaria, Germany

In atherosclerosis characterization of the so-called vulnerable plaque, which is at risk for disruption, is critical to predict acute adverse events. In this study we demonstrate the ability to identify complex, vulnerable atherosclerotic plaques in a rabbit model of carotid artery atherosclerosis combining morphological and functional information in simultaneous PET/MR imaging.

Keywords

ability able accumulate achieved acute adverse agency agent agreement anatomical another approved around arrows arteries artery atherosclerosis attenuation attractive axial balloon bands biograph blood body called carotid cause channel characterization characterize cholesterol circulation clinic coil coll collateral combine combining complex complicated components confirmed contrast corrected correction critical dark death degree denudation diet differently diffuse discriminate disruption double dynamic eight either emission emissions enables enhanced events excised extent flight flow functional fused fusion good highly histological histology human identify identifying indicating inflamed inflammation inherent injection injured integrated invasive inversion lead list local localization medical medicine metabolic minutes mode model molecular morphological morphology nuclear objectives obstructed obstructing plaque plaques positron post preliminary preparation proposed rabbit rabbits radiology recovery resolution revealed risk saturation scanner shorter simultaneous simultaneously since skinner slice southern spin static studies subsequently supplied supported surgery tomography tracer turbo uptake vascular vessel vessels vulnerable wall week weeks western whole world yellow yuan