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Abstract #3809

Quantitative Assessment of L-Type Calcium Channel Activity by Manganese-Enhanced MRI

Kai Jiang1, 2, Ya Chen1, 2, Raymond F. Muzic, Jr., 13, Xin Yu1, 2

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States; 3Department of Radiology, Case Western Reserve University, Cleveland, OH, United States

A mathematical model was developed for quantitative assessment of the L-type calcium channel activity with manganese-enhanced MRI. Dynamic changes in R1 during manganese perfusion and wash-out were followed with rapid T1 mapping at 3 min temporal resolution. Manganese uptake via the L-type calcium channel and efflux via the NCX were estimated by least-squares fitting of the model to experimental MEMRI data.

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Keywords

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