Meeting Banner
Abstract #3808

Carnitine Supplementation in Long-Chain Acyl-CoA Dehydrogenase Knock-Out Mice Is Not Detrimental for Cardiac Function

Adrianus J. Bakermans1, Michel van Weeghel2, Klaas Nicolay1, Jeanine J. Prompers1, Sander M. Houten2

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 2Laboratory Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, Netherlands

Elevation of long-chain acylcarnitine levels is a hallmark of long-chain fatty acid β-oxidation disorders, and is accompanied by low free carnitine levels. To normalize carnitine concentration, carnitine supplementation has been proposed. However, this could provoke lipotoxic accumulation of long-chain acylcarnitines.

Keywords

abnormalities academic access accompanied accumulation acid addition affect aging analyzed anesthetized animals arrhythmias assess assessed biomedical birdcage body bonnet bore bottom built cardiac chain chess cine circulation clinically collected content controls cradle decreased deficient derived described determined detrimental diastolic diet diseases disorders display dose drinking ejection elevated elevation enable enhance entered equipped evidence exert farm fatty finally fixed fraction free function gated gating genetic genotype hallmark heart horizontal housed hypertrophy in vivo indicating invasive investigated knock laboratory linear localized long made male mass matrix medical metabolic mice mild mixed model module monitor morphology mouse myocardial myocardium normalize normalizing oxidation patients positioned preceded press profile profiling proposed protocol quadrature quantified random received reception relevant repeated resonator respiration respiratory rodent sander semiautomatic septum served significance signs slice software spectra spectroscopy statistical storage subsequently supine supplement supplementation suppressed suppression system tandem technology tissue toolkit traits transmission triggered triggering triglyceride unaffected unsuppressed ventricular vital water weeks whereas