Meeting Banner
Abstract #3746

A Comparative Study of RCBF Maps with Arterial Spin Labeling and FDG-PET in Dementia and Alzheimer's Disease

Pablo Garcia-Polo Garcia1, Juan Antonio Hernndez-Tamames2, Roberto Garca-lvarez3, Eva Alfayate4, Juan lvarez-Linera5

1Neuroimaging Lab., Centre for Biomedical Imaging, Pozuelo de Alarcn, Madrid, Spain; 2Universidad Rey Juan Carlos, Mstoles, Madrid, Spain; 3Research and Collaborations Department, GE Healthcare, Buc, France; 4Cien Foundation - Centre for Alzheimer's Disease Queen Sofia Foundation, Madrid, Spain; 5Hospital Ruber Internacional, Madrid, Spain

Alzheimer's disease (AD) is a type of dementia that exhibits decreased perfusion-metabolism and GM loss in the brain. This work examines the correlation between both rCBF-ASL and FDG-PET in a group of 24 subjects. In addition, ASL was utilized in a second group of 99 subjects (Control, MCI and AD) to assess hypoperfusion in AD. Significant correlation between rCBF and FDG-PET was found. Hypoperfusion patterns were seen in posterior cingulate and posterior lobes in AD. This work demonstrates both: a high correlation between ASL and FDG-PET, and the capability of ASL to become a promising technique to monitor the AD.

Abstract PDF E-Poster Video

Keywords

acquisition agents aging allows annals around array assess assessed axis blood board body bolus bottom brain carotid cause cerebra cerebral classified coded coil color columns conditions consent contra control controls correlation correspond cortical decline decrease decreased deficits dementia dementias dings discovery disease diseases displays divided early ease elder emission find flow focused formed foundation future gender gene generate gold guidelines health healthy highlighted highly hospital identical important indicative induced inferior info invasive labeling linear lobes loss machine made mapping maps mixed mode monitor near neural neurology paired part participating pathologic patient patients patterns perfusion polo positron posterior prior probabilistic promising pulse quantification regional resolution reveal revealed review rows rube scheme significantly slices spin stage statistical sting stud studies subgroups subjects substitute superior template tomography unaltered utilized validity various volume ween years young