Meeting Banner
Abstract #3727

Diffusion Spectrum Imaging Tractography Study of Ventral and Dorsal Pathways for Language in Schizophrenia

Chen-Hao Wu1, Hai-Go Hwu2, Chih-Ming Liu2, Chen-Chung Liu2, Chung-Ming Chen3, Wen-Yih Isaac Tseng4, 5

1Institute of Biomedical Engineering, National Taiwan University,, Taipei, Taiwan; 2Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 5Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Diffusion Spectrum Imaging Tractography Study of Ventral and Dorsal Pathways for Language in Schizophrenia Schizophrenia is a mental disorder that goes along with progressively feeble symptoms. The clinical manifestations include auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking with significant social or occupational dysfunction. Abnormalities within language-related brain structures have been associated with clinical symptoms in schizophrenia. Recent functional and anatomical studies suggest that two distinct white matter tracts, called ventral and dorsal pathways provide communication between the two regions that are crucial to language processing. In this study, we used diffusion spectrum imaging tractography to reconstruct the connections involved in the ventral and dorsal pathways for language and to study the alteration of its structural connectivity in schizophrenia.

Abstract PDF E-Poster Video

Keywords

able according adult adults alteration alterations analyses anisotropy auditory balanced bilateral biomedical biomedicine bizarre brain bull bundle calculating called clinical college communication computing connections connectivity constituent controls correlations criteria crucial decomposing decrease decreased delusions determined deviation diagnosis differ diffusion disorder distinct dorsal either encoding engineering excitement feeble fiber formula fractional frontal fusiform gender general goes gradients grid hallucinations handed handedness healthy hospital house impairment implies imply include independent index indicate inferior institute integrity involved language lateralization leftward linear matched matrix measured measures medical medicine ming model moment moreover national natl negative optoelectronic orientations paranoid partial pathway pathways patients pattern percentage placed planar positive predictive predictor processing progressively proposed psychiatry radial recent reconstruct refocused regression related relationship representing respectively sample sampled schizophrenia scores sensitivity several severity significantly sites slice social spectrum speech structural structures student studies studio suggest superior symptoms system table thinking tract tracts trio twice units variables ventral white written