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Abstract #3726

Altered Functional Significance of Structural Connectivity for Language Processing in Autism Spectrum Disorders

Yu-Chun Lo1, Susan Shur-Fen Gau2, Wen-Yih Isaac Tseng, 13

1Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

This study investigated structural connectivity of the dorsal and ventral pathways of the language network using diffusion spectrum imaging tractogrpahy, and its functional significance corresponding to verbal IQ (VIQ) and verbal comprehension index (VCI). The results showed that structural connectivity of the left dorsal pathway in neurotypicals was associated with VIQ (r = 0.493, p=.0027), whereas structural connectivity of the left ventral pathway was associated with VCI (r = 0.447, p=.0048). These findings suggest that the functional significance of structural connectivity for language processing is altered in ASD.

Keywords

absent adapted administered adolescents altered anisotropy asymmetry atypical autism balanced basis better biomedicine blue brain bundles called channel child clinical coil college communication compensate comprehension computing confirms connectivity constituent correlated correlation corresponds criteria decomposing deficit deficits density despite determined diagnosis diffusion directional disorders dorsal edition encoding exploratory feature fiber fletcher fractional frontal full function functional fundamental fusiform gradients greater grid handed head hospital hypothesized impaired implies index individual inference inferior intelligence known language little local longitudinal matched matrix medicine might moment national nature occipital optoelectronic orange orbital orientation orientations original pair panel part participants past path pathological pathway pathways patients performance pervasive phenotype planar positive positively processing projected psychiatry quantified radial rather reconstructed reconstruction recruited refocused relationship report resolution resorted responsible scale scores selected sensitivity several significance slice spatial spectrum streamline striking structural superior symptoms syndrome system table tasks tract tracts trio twice upper variance ventral verbal whereas white worse yellow