Meeting Banner
Abstract #3714

Fractional Anisotropy Differences in Basal Ganglia in Neurological and Neurodegenerative Disorders

Gonzalo Pajares1, Juan Antonio Hernndez-Tamames2, Pablo Garca-Polo3, Norberto Malpica2, Ana Ramos4, Juan lvarez-Linera5

1Fundacin CIEN - Fundacin Reina Sofa, Madrid, Spain; 2Universidad Rey Juan Carlos, Spain; 3Centro de Tecnologa Biomdica, Spain; 4Hospital Universitario 12 de Octubre, Spain; 5Hospital Ruber Internacional, Spain

The aim of the present work is to study differences in the basal ganglia in several diseases, using Diffusion Tensor Imaging. Although no differences in gray matter are expected when using this technique, an increase in Fractional Anisotropy values has been observed in patients with respect to controls. Depending on the pathology, this increase affecs different structures: substantia nigra in PD; pallidus, putamen and substantia nigra in PSP, or pallidus, putamen and frontal cortex in m-MCI and AD. These results seem to related to the accumulation of iron in the brain.

Keywords

abnormal accumulation additional advantage affected affects aging although anisotropy anyway appear applied applies applying appraise artifacts basal brain carrying cerebral characterizing children cognitive comparing computed concentration construct control controls correcting cortex create deep depending deposition deposits diagnosis diffusion disease diseases disorders eddy eight essential every expected explained field finally forty fractional frontal ganglia general gray hospital hypotheses illness impairment in vivo included initially iron journal kernel know lateral linear literature major mapping maps material mentioned mild model need neurobiology neurological nineteen normalized noticeable origin paired palsy parametric pathological pathologies pathology patients plausible plus polo populations presence progression progressive radiology reason recently regarding registered respectively sclerosis seventeen several siblings significantly smaller smoothed software spatial stage staging statistical statistics structures studied studies subject subjects susceptibility syndrome template tensor thalamus thirteen transformation tremor twenty typically unknown white windows