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Abstract #3697

The Voxel-Based Comparison of Fractional Anisotropy and Mean Diffusivity Between the Elderly and Young Using TBSS

Fan-Pei Gloria Yang1, Yao-Chia Shih2, 3, Ming-Chieh Mindy Fang1, Kayako Matsuo3, Shen-Hsing Annabel Chen4, Toshiharu Nakai5, Wen-Yih Issac Tseng3, 6

1Department of Foreign Languages and Literature, National Tsing Hua University, Hsinchu, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 4Division of Psychology, School of Humanities and Social Sciences, Nanyang Technological University, Singapore, Singapore; 5National Center for Geriatrics and Gerontology, Aichi, Japan; 6Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Age related decreases in fractional anisotropy (FA) and increases in mean diffusivity (MD) were observed across the entire white matter (WM) skeleton as well as in specific WM tracts. In this study, TBSS was applied to FA and MD images to examine the differences in WM integrity between healthy elderly and young participants. The efficient registration by TBSS successfully demonstrated the differences between healthy young and elderly groups. FA and MD shared the most significant difference in corona radiata. In conclusion, the findings demonstrate the effectiveness of TBSS as a population-wise measure of the WM change on a voxel-by-voxel basis.

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Keywords

addition adults aged aging ahead anisotropy anterior applied avoid balanced basis biomedical biomedicine brain capsule certain channel characteristics cluster coil college commonly compute conducted consistent controls corona corpus correction cost created cross datasets decreases degenerates degeneration detailed diffusion diffusivity division effectiveness efficient elderly engineering enhancement entire essential examine examined extraction fang field finally findings foreign fractional free functions general geriatrics gerontology greatest handed head healthy hospital humanities hypothesized individual institute integrity internal japan languages linear literature longitudinal male manner maps matrix measure medical medicine ming minimize motion national nonparametric normalization normalize numerous older optoelectronic parametric participants patients permutation planar poor population posterior previous print psychiatry psychology radiation randomize reduction refocused registration related repeated salami scenario school sciences sensitivity significantly skeleton slice smith social source spatial statistical statistics subject successfully superior system technological template tensor thirty threshold tools tract tracts twenty twice versus view volumes white widespread wise yang years young younger