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Abstract #3696

VBM Study of Diurnal Variations of Brain Diffusion in Healthy Adults

Chunxiang Jiang1, Lijuan Zhang*1, Xiaojing Long1, Weiqi Liao1, Wenhui Huang1

1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, Guangdong, China

Diurnal alteration of diffusion parameters were observed in grey and subgyral white matter of healthy human brain. Peak ADC changes were found to locate in bilateral occipital lingual and calcarine regions while peak FA changes were located in the frontal lobes. Changes in brain diffusion parameters may reflect the underlying circadian physiological variations of human brain.

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Keywords

academy addition adult adults advanced affine aligned alterations altered anisotropy applied attribute bilateral biological brain china cluster clusters coded cold color complete computed concentrations conditions considered continuous coordinates corrected correction coupled detail diffusion diffusivity directional diseased distortion diurnal diurnally eddy evening examined explore exploring extensively extracellular females field filter finally frontal gradient greater head healthy hemisphere hour implemented induced institute institutes investigation isotropic lingual lobe lobes long longitudinal mainly males mapping maps materials maximal medial miller morning motions neurotransmitter normalization normalized occipital paired parametric participant pathology peak people percentage period physiological physiology pixel planar predominantly processing recruited reflected regional repeated representative republic resolution rest rhythm sciences score sensitized shot smoothened software space statistical statistically student studio subjects suggested summarized table tables technology template temporal tensor tissue transformation transverse underlying variation variations varies view volume warm white years