Meeting Banner
Abstract #3675

Functional MRI of Working Memory in Patients of Mild Traumatic Brain Injury

Yen-Peng Liao1, Chi-Jen Chen1, Chih-Hsiung Wu2, Hui-Ling Hsu1, Ying-Chi Tseng1, Ho-Ling Liu3, Wen-Ta Chiu4

1Department of Medical Imaging, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, Taiwan; 2Surgery, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, Taiwan; 3Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan County, Taiwan, Taiwan; 4Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei City, Taiwan

Previous functional MRI studies of mild traumatic brain injury (MTBI) patients have indeed shown altered patterns of activation during working memory (WM) task. However, the results were inconsistent. This study aimed to analyze the brain activation patterns in response to n-back WM loads after MTBI. The results showed that MTBI-induced differences in WM functional activity were observed in the absence of differences in neuropsychological performance, suggesting that this approach may increase sensitivity to MTBI compared with neuropsychological evaluation alone. The results also lend further evidence to the potential for cerebral plasticity to maintain performance levels on WM tasks after MTBI.

Keywords

ability absence accuracy activation aforementioned aimed alone altered among analyze analyzed approved back brain cerebral channel circuitry city coil collected college committee computer condition conditions conducted consent consisted contained continuous contrary control controls controversy convinced cortex counterbalanced county coworkers decreased desktop diagnosed differ differed digit discovery education eight ensure enter epoch epochs equally ethics evaluation evidence explore externally field fixation function functional gave graduate handedness head healthy hospital hospitals illness impaired implemented improvement inconsistent increasing indeed induced informed initial injury inside installed institute inter lend ling load loads local maintain maintained mapping maps materials matrix medical memory mild millisecond moderate neurological outside parametric parietal participants participating patients patterns performance planar plasticity posterior potential preceded presentation prevention previous prime prior processing prospective psychiatric radiological recruited repetition response scanning sciences screened sensitivity settle significantly slice span statistical studies subjects suggesting surgery system task tasks trained traumatic uncorrected version view volunteers week written years