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Abstract #3602

High Resolution ex vivo Diffusion Kurtosis Imaging of Chronic Perilesional Brain Changes in a Rat Stroke Model

Umesh Rudrapatna1, Pavel Yanev1, Karsten Ruscher2, Annette van der Toorn1, Tadeusz Wieloch2, Rick Dijkhuizen1

1Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Laboratory for Experimental Brain Research, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

Elucidation of structural plasticity in lesion borderzones after stroke

Keywords

ability acquisitions active acute aimed allows alteration ample animals artery assess assume attributed beginning besides biomedical blue book brain brains capable cellularly cerebral characteristic chronic clearly cold combined confidence contrast cook cortex cortical deducing delineated desirable detection diffusion diffusivity discriminating diversity ellipses elucidating enhanced equipped essentially exhibit experimental extent extra filament fits fixation fixed focal fractional generally healthy help hemisphere heterogeneity highlight highly homologous important in vivo injury insert inside intact interleaves intervals keenly kurtosis laboratory leading made magnet maps markedly marker matrix measures mechanisms middle model nature need neuronal observations observe occurred occurs operating optimized package pairwise perfusion period perpendicular placed plasticity popular post potentially previous procedure processes proposed rats reconstructed recovering recovery regarding remodeling repeated resolution respectively revealed role sacrificed sciences scores sensitive sensitivity serve seven significance significantly slice sodium spectroscopy sprouting stages still stored strategies stroke structural structures take though tissue treatment typical undergo undergoes understanding unravel ventilated weeks white