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Abstract #3563

In Vivo Human Brain Measurements of Axon Diameter Distributions in the Corpus Callosum Using 300 MT/m Maximum Gradient Strengths

Jennifer A. McNab1, Thomas Witzel1, Himanshu Bhat2, Keith Heberlein2, Boris Keil1, Julien Cohen-Adad1, M. Dylan Tisdall1, Lawrence L. Wald1, 3

1A.A. Martinos Center for Biomedical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; 2Erlangen USA Inc., Siemens Medical Solutions, Charlestown, MA, United States; 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

In this work we use a novel gradient coil AS302 which is part of a new 3T system (MAGNETOM Skyra CONNECTOM, Siemens Healthcare) capable of up to 300 mT/m to measure, in the in vivo human brain, the full axon diameter distribution in the corpus callosum as determined by the AxCaliber method.

Keywords

ability accuracy achieve acquisition acquisitions adequately applications applied array attenuation attributes availability available axon axons biomedical blueprint body bounds brain capable channel clinic clinical closely coefficient coil commercially component components conditions conduction consisted corpus currently custom demonstrations describe determined developed diameter diameters diffusion distribution distributions division drawn employs enable encoding equal estimating expected experiment experimental extensively extra five fixed fraction full funding future gamma general gradient grant greater hand health hindered histology hospital house human impeded important in vivo index initial institute insufficient invasive isotropic larger least limitations limited literature made maximal measure measured medical methodology minimization minor minutes model modeled models modifications morphology necessary note novel opens part pathways performance perpendicular physiological preliminary prevent previous previously prior product progress quantify radiology recently related resolution restricted sample sampling scanned scanner scanners school sensitivity series slew slice space specimens spectrum spins square strength strengths studies system table technology tissue translation ultra utilizing validated velocity