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Abstract #3526

Quantification of Contrast Agent in Human Brain Using Quantitative Susceptibility Mapping

Tian Liu1, Yinghua Ma2, Min Lou3, Timothy Vartanian2, Yi Wang4

1MedImageMetric LLC, New York, NY, United States; 2Neuroscience and Neurology, Weill Cornell Medical College, New York, United States; 3Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, China; 4Radiology, Weill Cornell Medical College, New York, United States

In Vivo quantification of contrast agent using T1/T2* based methods are subject to large errors due to quenching effects. On the other hand, superparamagnetic iron oxide or gadolinium based contrast agents are highly paramagnetic, making them ideal candidates for quantitative susceptibility mapping. In this study, we demonstrated the feasibility of using QSM for the investigation of vasculature in the human brain tumor.

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Keywords

accumulation accuracy accurate adult affiliated agent agents amounts appears applied averaging avoided background birdcage blood brain brains caused channel china coil collected college computing condition containing contrast converted convolution create critical currently demonstrating depicted diagnosis dipole distribution enabled endothelial enhanced enhancement equation error estimating experiment field flow free gadolinium good gradient hang head hospital human immediately impression in vivo indicated induced injected injection intensity iron isotropic kernel kinetic known limited linearly local loss magnets magnitude many mapping masses measuring medical medicine mice modern molar moment mouse needle negative neurology offers outer paramagnetic patients pattern patterns people peripheral periphery permeability phys positive possibly post potential preferentially presence problems profile prognosis proportional quadrature quantification quantified quantify quantitative quenching radiology reception reconstructed related reliability rendered report resolution saturation scaled scaling scanner school section sources spacing stroke subject subsequently substance summing susceptibility timothy tissue traditional transmission tumor tumors underestimation uniform valuable various vessel view volume wall withdrawal