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Abstract #3525

An Automatic Computation Tool for the Estimation of B1-Corrected Pharmacokinetic Parameters

Robert Merwa1, Gernot Reishofer2

1Medical Engineering, Upper Austria University of Applied Sciences, Linz, Austria; 2Department of Radiology, Medical University of Graz, Graz, Austria

DCE T1-weighted MRI provides a technique for the determination of human tissue parameters. For field strength above 1.5 T B1-inhomogeneities occur which produce considerable intensity variations and the estimation of these tissue parameters fails. In order to tackle this challenge a huge amount of images and complex mathematical calculations are used hence the manual handling is pretty difficult and not fail-save. The aim of this work was to develop a software package for the automatic calculation of the (a) T1-relaxation time, (b) concentration of the contrast agent, (c) AIF in a major artery and (d) tissue parameters for defined regions.

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Keywords

able acquisitions additional adjustment agent amount applied arterial artery automatic automatically blood calculation calculations challenge chosen coefficient collaboration complex computation concentration concentrations considerable constant contrast correct corrected correction database deconvolution defined dependent determination determined develop developed deviation differential difficult displayed easy engineering enhanced equation estimation examination extracellular fail fails field filter function functional functions furthermore general gradient graphical guided handle handling hence hospital hospitals huge human implement implementation implemented improved index inhomogeneities inhomogeneity input intend intensities intensity interface interpolation kernels kind kinds kinetic listed longitudinal major makes manual mathematical media medical menu mode model mouse noise occur operation package patient perfusion plasma polygons post pretty principle processing produce quantification radiology read relies removal repetition represents respect respectively save sciences selected series settings smoothing software space special statistical stored strength stroke summary system tackle temporal tissue tool tools tracer trans transfer unit upper user variance variant variation variations various volume whereby whole