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Abstract #3507

Effect on Time Duration on the Precision of Pharmacokinetic Parameters in DCEMRI

Kumar Rajamani1, Dattesh Shanbhag1, Rakesh Mullick1, Sandeep N. Gupta2

1Medical Image Analysis, GE Global Research, Bangalore, Karnataka, India; 2Biomedical Image Processing Laboratory, GE Global Research, Niskayuna, NY, United States

We have demonstrated the precision of pharmacokinetic parameters and its effect due to duration of the time-intensity signal. Our results demonstrate that for the prostate case it is preferable to have scan duration of 5 minutes. Scan durations of more than 6 minutes do not generally contribute to any further improvement in the parameters.

Keywords

acceptable accuracy achieve analyses appropriate approving approximately arrival auto automatic beyond biomedical blood bolus carried challenges characterization clinical coil comparable compartment complete compute computed computing concentration considered contrast control curve curves database datasets derived described detection determination duration durations dynamic dynamically enhanced enhancing entire estimation evaluated execution experiment experimental extra fidelity filtered findings fitting flow fraction fractional functionality generally give global gold ideal identified implementation improvement injection input insight intensity introduced invasive kinetic laboratory lancet landmarks lead lesion library longer majority manually maps materials matrix measured methodology minutes model modeling models modes nonlinear observations observe optimal ordinates perfusion phys picked plot population potential precision preferable processing prostate protocol protocols providing quantitative reliability reliable required respectively routinely seem settings setup side site slices software statistical statistics step steps stored studied studies synthetic text thank threshold thresholds tool toolkit torso tumor variability variable variation varied various vector vessel volume volumes widely women zones