Naoki Ohno1, 2, Tosiaki Miyati2, Mitsuhito Mase3, Tomoshi Osawa3, Harumasa Kasai4, Hirohito Kan4, Masaki Hara4, Yuta Shibamoto4, Akihiro Kitanaka2
1Department of Radiological Technology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan; 2Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan; 3Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan; 4Department of Radiology, Nagoya City University Hospital, Nagoya, Japan; 5Department of Radiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
We assessed normalized ADC in white matter in patients with idiopathic normal-pressure hydrocephalus (INPH), atrophic ventricular dilation, and in healthy volunteers to determine the degree of fluctuation of water molecules independently of the water amount. Normalized ADC in INPH were significantly higher than those in the control and atrophic ventricular dilation groups. Water amount independent analysis may render it possible to noninvasively obtain more detailed information than that provided by standard ADC measurement in suspected INPH, potentially facilitating the diagnosis of this disease.