Meeting Banner
Abstract #3090

Alteration of Metabolites in the Lateral Septum of Peripubertally Stressed Rats

Nathalie Just1, Matthieu Auffret1, Guillaume Poirier2, Maribel Cordero2, Carmen Sandi2, Rolf Gruetter1, 3

1LIFMET, CIBM/EPFL, Lausanne, Switzerland; 2Behavioral Genetics, Brain Mind Institute and EPFL, Lausanne, Switzerland; 3Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Switzerland

There is increasing evidence that a link exists between exposure to stress in early life and long-term alterations to brain function, which in turn have been linked to psychiatric and neurological disorders in humans. In the present work, proton magnetic resonance spectroscopy was used to examine the metabolic effects of peripubertal stress on the offsprings of control rats and male rats themselves submitted to peripubertal stress. The lateral septum was chosen as the area of interest due to its role in stress mechanisms. GABA concentrations were significantly reduced in the peripubertally stressed offsprings. These findings correlated with immunochemistry measurements.

Abstract PDF E-Poster Video

Keywords

according adjusted adult adulthood aggression aimed alteration alterations analyses analyzed anesthetized animal animals atlas basal behavioral better blocks brain capable caused challenge circulating coil concentrations consequences continuous control days decreased density described detecting disorders displayed easy elevated emotional emphasizing enzyme epigenetic episodes examine examined exhibited exposed faced foundation foundations general genetics glutamate good gradient gradients grants holder hormones impact implicated in vivo injection involved lateral localized location long magnet maintenance male males marker mechanisms metabolic metabolite metabolites mind minutes model modifications modulated modulating molecular national negatively neuronal nitric odor offspring often open oxidative particular period physiological placed post potential predator press previous processes profile proteins proton psych psychiatric quadrature radiology rats receive recent rectal reduction release restoration revealed role search septum shielded shimming shims short significantly spaces special spectra spectroscopy statistical stress stressed studies subject subjected submitted synapse synthesizing table temperature term transmit treatment typical understanding undisturbed unfamiliar universities unpredictable upon viability water