Meeting Banner
Abstract #3087

Multi Nutrient Enriched Diets Restore Cerebral Perfusion and Protect Against Neurodegeneration in a Mouse Model for Alzheimers Disease

MAGNA25Valerio Zerbi1, 2, Diane Jansen1, Maximilian Wiesmann1, Maartje Mutsaers1, Pieter J. Dederen1, Ilse Arnoldussen1, Andor Veltien2, Sjaak Van Asten2, Arend Hee

1Anatomy, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Increasing evidence supports the importance of lifestyle especially dietary intake, in sharing a protective action in Alzheimers disease (AD) and cardiovascular diseases. In this study, we therefore evaluated the effects of a long term dietary intake of multi-nutrient lipid diets on cerebral blood flow (CBF) and hippocampal metabolite levels in an AD mouse model (APP/PS1). Results showed that 12-month-old APP/PS1 mice have decreased CBF and that specific combinations of multicomponent enriched diets are able to restore cerebral perfusion into physiological values, with signs of decreased neurodegeneration, suggesting a potential efficacy of multi-nutrient lipid diets in slowing AD progression.

Abstract PDF E-Poster Video

Keywords

absolute acid acids actively agreement alternating ameliorates analyzed anatomy animals antioxidants biochemically blood brain calculation cardiovascular cells cerebral choline circular clearly clinical cofactors cognitive coil combination community components conditions containing control corpus cortex cortical decline decrease decreased delay dependent determined diet dietary diets disease double enhance enriched epidemiological equipped equivalent evaluated failure fair familial fatty findings five flow formation framework funding genetic good gradient grant hypothesized incremented interleaved inversion leading long maintaining male management maps matrix mayo measured medical membrane metabolite mice minutes model models month months mouse neuronal nutrient nutrition omega particularly pathology patients perfusion physiological pixel plaques positive possibly potential precursors previously processes proposed protect protective protects published quantified radiology receiving recently recovery reduced regional reported resolution resonator resting restore revealed review risk selective seventh several shielded significantly slight spatial spin strongly studies successfully suggest supplementation synapses synthesis system terms thalamus tissue together towards transmission trials type vitamins wild