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Abstract #3086

Biomarkers of Epileptogenesis in Temporal Lobe Epilepsy: Quantitative MRI and EEG

Zuyao Y. Shan1, Irina Kharatishvili1, Nyoman D. Kurniawan1, David C. Reutens1

1Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia

Following an initial brain injury, dynamic changes in brain lead to the development of spontaneous recurrent seizures, i.e., epileptogenesis. Understanding of mechanisms of epileptogenesis is key to the development of treatment strategies. This study combined quantitative ultra high-field MR with EEG to characterize epileptogenesis-related changes in TLE mouse model. Dynamic changes were observed in HC, AMG, and PHC following status epilepticus (SE) at different times post-SE. The MR changes in HC and thalamus at day 7 was significantly correlated with spike frequency on EEG. This finding suggests a critical time point during the latent period of epilepsy development.

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Keywords

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