Meeting Banner
Abstract #3084

Correlation of Motor Coordination with in vivo Metabolite Ratios in Lysophosphatidyl Choline Induced Demyelination Model of Multiple Sclerosis: A Sequential In-Vivo Proton MRS Study

Krithika Balasubramanian1, Uma Sharma1, Senthil S. Kumaran1, Anjali Chauhan2, Yogendra K. Gupta2, Naranamangalam R. Jagannathan1

1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Correlation between motor coordination changes and in-vivo metabolite ratios was studied at different stages of de- and re-myelination in an experimental model of multiple sclerosis. Demyelination was induced using lysophosphatidyl choline in the internal capsule (ic) area of rat brain. Significant correlation was observed between motor coordination and metabolite ratio which was attributed to the damage to the myelin around the motor fibers during demyelination leading to decreased N-acetyl aspartate (NAA) and increased choline (Cho). The motor coordination subsequently improved during remyelination resulting in increased NAA and decreased Cho.

Abstract PDF E-Poster Video

Keywords

activity acute aids alter assessed biochemical biochemistry body brain choline chronic comp considerably consists contrast control correlated correlation creation damage days decreased destruction deviation difficult disability disease disorder done dysfunction error expected experimental facility fault fibers focal focused foot function gain gives grip head hence human improvement improvements in vivo indicates indication indicator indispensable induced inflammatory injection institute integrity internal leading leads lesion loss mainly marker medical metabolism metabolite metabolites model motor namely nation near negative neuronal norm objective occurring onwards ordination paired patients plot ported positive prior progression proton rats reached reaching reduced reduction reflect reported rota rotor sciences sclerosis sequential serve served serves severity sheath significantly since spectra spent stages steps strength strong structure studies subsequently system table temporary till tissue tool valuation various versed weakens white width