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Abstract #3059

MRS Assessment of Lactate in Dedifferentiated Liposarcoma Models Treated with Chemotherapy

Asif Rizwan1, Xiaohui Ni1, Rachael O'Connor2, Samuel Singer2, Sean Carlin3, Jason Koutcher1, Kristen L. Zakian1

1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 3Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

The lack of effective chemotherapy in de-differentiated liposarcoma leaves non-surgical candidates with few options. A non-invasive marker reflecting the effect of drugs could be quite valuable in pre-clinical drug evaluations. Furthermore, in the clinic, an early marker of response/non-response could permit the physician to discontinue ineffective treatment. Lactate, an end-product of glycolysis has the potential to be a biomarker of prognosis and treatment effect. The goal of the current study was to assess the change in lactate levels in a human DDLS tumor xenograft implanted in mice in response to chemotherapy.

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Keywords

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