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Abstract #3058

In Vivo Lactate T1 and T2 Relaxation Measurements in Breast Tumors Using SS1-SelMQC Editing Sequence

Sanjay Annarao1, Thomas Ku2, Kishore Nagavara3, Jason Koutcher1, 4, Sunitha Thakur1, 3

1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Department of Molecular Pharmacology & Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 3Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 4Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

SS1-SelMQC pulse sequence is proposed to detect Lac with enhanced signal intensity by effectively suppressing fat and water using 1331 binomial composite Spectral-Selective Pulses in Selective MQ Coherence (SS1-SelMQC). Lac signal enhancement was achieved by using short binomial frequency selective pulses, which reduces signal loss in the evolution period due to the effects of scalar coupling and molecular diffusion. T1 and T2 of Lac incorporating T1 and T2 variables in SS1-SelMQC. T1-SS1-SelMQC and T2- SS1-SelMQC is standardized in phantom and demonstrated in in-vivo breast tumors. The T2 of Lac was statistically different in different types of breast tumors.

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Keywords

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