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Abstract #3023

Probing Tumor Early Response to Radiation Therapy Using Hyperpolarized [1-13C]pyruvate in a Breast Cancer Model

Albert P. Chen1, Yi-Ping Gu2, Michelle Ladouceur-Wodzak2, William Chu3, Charles H. Cunningham2, 4

1GE Healthcare, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3Radiation Oncology, University of Toronto, Toronto, ON, Canada; 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Changes in the [1-13C]lactate signal observed in vivo following injection hyperpolarized [1-13C]pyruvate have been shown to be a marker for early treatment response. With the emergence of hypofractionated radiation therapy, this tool for detecting early response to treatments non-invasively may be very important for management of certain cancers. In this study, early and significant change in hyperpolarized [1-13C]lactate signal in tumors was observed after a single, large dose of radiation therapy in a human breast cancer model.

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Keywords

acid acquisition agent agreement anatomical animals approximately arrival beginning biophysics bottom breast cancer cancers certain characterization chelate coil control controls course courses decrease degrees delineation detecting development diameter dissolved doped dose dual early effective either elevated emergence established excellent excitation feasibility funding future going hardware harvested health helpful hind human important improve in vivo included injected injection instruments international invasive isotropic kidneys laboratories lactate lead localized management marker mechanism medical metabolic metabolite micro model models neat novel nude observation oncology oxford patients persistent ping planning plotted polarize polarized polarizer post prior probing protocol protocols radiation radical rats reduction representative resolution resolved respectively response scanned scanner scanning sciences shield slightly spatial spatially spectral start started statistically strip students studies subcutaneously substrate substrates summed supported temporal therapeutic therapy tool treated treatment treatments tumor tumors tuned understanding untreated volume