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Abstract #3022

Rat Liver Tumor Treated with a Vascular Disrupting Agent Combined with an Antiangiogenic: Enhanced Antitumor Efficacy Evaluated by MRI

Feng Chen1, Kaier Zheng2, Frederik De Keyzer1, Raymond Oyen1, Yicheng Ni1

1Radiology, University of Leuven, Leuven, Brabant, Belgium; 2Radiology, BenQ Medical Center, Nanjing Medical University, Nanjing, China

Our randomized, controlled study demonstrated that the combination of a vascular disrupting agent with an antiangiogenic (ZdTha) enhanced overall antitumor efficacy due to synergistic effects. ZdTha induced cumulative tumor necrosis, and thus, significantly decreased tumor volume and reduced the viable tumor rim; ZdTha also reduced tumor vessel permeability and improved tumor hemodynamic indexes via a transient normalization of tumor vasculature induced by Tha. Finally, the ADC value at 12 d was shown to be an independent predictor of changes in tumor volume. These therapeutic effects were successfully tracked and evaluated with in vivo multiparametric MRI.

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Keywords

agent alone among animals apparent approved arrow axial background cancer care cell cells china circulating coefficient combination combined committee control controls correlated cumulative delay delayed derived diffusion disrupting dynamic efficacy either endothelial enhanced ethical evaluated growth highest implanted improved in vivo independent indexes induced institutional laboratory largest likely linear liver measured medical monitored necrosis negatively normalization people permeability phys plasma potential predictor pretreatment problem progenitor quantified radiology randomized rats reduced reduction reductions regression regrowth representative republic residual significantly since solid solution stepwise studied successfully synergistic thalidomide therapeutic therapy tracked transient treated treatment tumor tumors vascular verified vessel viable volume volumes