Meeting Banner
Abstract #3003

Correlation of Molecular Biomarker (ER, PR, HER2/neu Status) with Total Choline Concentration and Tumor Volume in Breast Cancer Patients: Using an MRI and in vivo Proton MRS

Naranamangalam Raghunathan Jagannathan1, Rani G. Sah1, Uma Sharma1, Vurthaluru Seenu2, Sandeep Mathur3, Rajinder Parshad2

1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India; 3Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

The total choline (tCho) concentration and tumor volume were determined using in-vivo MRS and MRI in 73 invasive ductal carcinoma patients at 1.5T with known HER2/neu, ER and PR status. The tCho concentration in HER2+ (3.81.2), ER+ (5.02.7) and PR+ (5.02.8) patients was not significantly different as compared to HER2- (4.4 2.9), ER-(4.32.8) and PR- (4.72.9) patients. Tumor volume in ER+ patients was significantly lower compared to patients with ER-. The increase in the volume may be attributed to higher microvessels density in ER- patients. Also no significant difference in tCho concentration and tumor volume was observed with PR status.

Abstract PDF E-Poster Video

Keywords

according analyses approved association attributed available axial basal better breast calculation cancer cancers carried categorized category characterized characterizing choline clinical clinically committee comprising concentration controls coronal correlation denotes density detects determine determined diagnosis diagnostic differentiate epidermal estrogen ethical ever excluded expressing expression facility fall features five fluorescence formula growth help heterogeneity heterogeneous histology hormonal human immune important in vivo included indicated institute institutional internal invasive inverse larger lesions life like lipid malignancy malignant markedly material measured medical micro might minutes molecular nearly needle negative objectives options palpable pathology patient patients peak play plot positive potential presence prior progesterone prognosis protein proton quality quantitative reason reasons receptor receptors reduces regulated reported represents retrospective sciences score scores scout setting significantly since situ software specificity spectrum statistical statistically status stir student subjected subtypes suppression survival table therapy tissue treat treatment tumor tumors types understanding unique usually variation variations various volume volumes water wide women written years