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Abstract #3002

Association of Total Choline Concentration and Tumor Volume in Triple Negative (TN), Non-Triple Negative (NTN) and Triple Positive (TP) Breast Cancer Patients: An MRI and in vivo Proton MRS Study

Rani G. Sah1, Uma Sharma1, Rajinder Parshad2, Vurthaluru Seenu2, Sandeep Mathur3, Naranamangalam Raghunathan Jagannathan1

1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India; 3Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

tCho concentration and tumor volume were determined using in-vivo MRS and MRI in triple negative (TN), non-triple negative (nTN) and triple positive (TP) breast cancer patients. TN patients were of younger age (28 to 39 yrs) compared to nTN and TP patients. tCho concentration was significantly lower in TN (3.8 1.0 mmol/kg) compared to nTN (4.7 3.1 mmol/kg) and TP (5.4 2.5 mmol/kg) patients while tumor volume was similar in all patients. Reduced choline kinase expression and high degradation of phosphatidylcholine might have led to lower tCho in TN patients; however, this warrants further investigations.

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Keywords

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