Meeting Banner
Abstract #2384

A Theoretical Framework for DANTE Prepared Pulse Trains: A Novel Approach to Motion Sensitized and Motion Suppressed Quantitative MRI

MAGNA25Linqing Li1, Karla Miller1, Peter Jezzard1

1FMRIB, Clinical Neurology Department, University of Oxford, Oxford, United Kingdom

DANTE (a rapid series of low flip angle RF pulses interspersed with gradients)pulse trains may be employed for flow fluid signal suppression module. During application of DANTE pulse trains, longitudinal magnetization of flowing spins is largely (or fully) attenuated due to phase dispersion accrued while flowing along the applied gradient. This is in contrast to static tissue, whose longitudinal magnetization is mostly preserved. This progressive saturation of flowing spins is insensitive to velocity (above a threshold). This work is a theoretical framework for motion sensitized and motion suppressed quantitative MRI when DANTE is applied.

Keywords

abstract acquisition acquisitions agree agrees although analytical apparent application applied approximation arbitrary assessed assuming assumption attenuated attenuation background biomedical chosen classic clear clinical coherence component consider considered constant conversely course crushing curve curves decay delay deliberately derive desired despite disappeared dispersion displayed dominated dotted effective embedding employing equation equations equilibrium existing experimental expression extreme fast fields find flow flowing formulation framework freeman full generalize gradient hill in vivo indicating individual induced inserted interleaved interval intuitive kingdom largely long longitudinal magnetization magnetizations magnified manner matrix measured miller module motion moving muscle must neck neurology novel numerical objectives observations oxford partial partially period periods peter phantoms precession prepared preserves progressive proper proposed pulse pulses quantification quantified quantitative readout recovers represents respectively saturation sensitized short simple simplification simulation simulations situation solid spin spins spoiled spoiling starting static steady subsequent substantial substantially suppressed thank theoretical tissue train trains transient transverse treated understand validate velocity vessels water yield