Meeting Banner
Abstract #2383

Ultra High Resolution Imaging for Permeability and Stability Measurements of Microcapsules for Controlled Drug Delivery

Stefan Henning1, Daniel Edelhoff1, Sabine Leick2, Heinz Rehage2, Dieter Suter1

1Exp. Physics III, TU Dortmund, Dortmund, Germany; 2Physical Chemistry II, TU Dortmund, Dortmund, Germany

We present methods to evaluate the functionality of microcapsules used for controlled and site specific delivery of drugs. By quantitative measurements of time dependent contrast agent concentration in the capsules with micro scale MR imaging, we can obtain diffusion coefficients revealing how different capsule preparations decrease the permeability. In addition, we can also show how the capsules dissolve in intestinal media whereas they remain stable in gastric media by using a micro scale FLASH sequence.

Abstract PDF

Keywords

able achieved acidic acquisition agent agents application arising basic break capsule capsules champagne chem chemical coated coating coatings coefficient concentration contrast controlled core decrease delivery depending determine diameter dieter diffusing diffusion dissolution distance drug drugs encapsulated equipped excellent external flash function fusion gastric gastrointestinal gent hand helps henning inside intestinal knowing lash leading leads liquid long mall measure measuring media mental microscopy minute minutes molecules must observe optimize permeability phys physical physics placed plug potential prepared press pure reduce release resin resolution shellac side significantly simulated simulating simulation site solution stab stability stabilization stable sufficiently swell swelling took tool tube unit visualization weak