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Abstract #2080

Optimization of ICA for Detection of Weak and Focal Activations in FMRI

Waqas Majeed1, 2, Feng Wang1, 2, Robert M. Friedman3, Chaohui Tang1, 2, Malcolm J. Avison1, 2

1Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN, United States; 2Department of Radiology, Vanderbilt University, Nashville, TN, United States; 3Department of Psychology, Vanderbilt University, Nashville, TN, United States

In this study, we describe an approach for detecting weak and focal activity patterns in fMRI data. High resolution cerebral blood volume weighted images were acquired from squirrel monkeys during tactile stimulation of digits 1 and 3. The data were preprocessed to enhance effective contrast-to-noise ratio, and the model order was estimated in a data-driven fashion (based upon stability of the principal modes). Activation patterns associated with stimulation of individual digits were successfully detected using ICA. In future, we intend to use this approach to investigate the presence of local functional connectivity networks within the somatosensory cortex of squirrel monkeys.

Keywords

abbreviated accuracy accurate accurately achieved activated activation activations actuators adjusted agent alternating amount amplitude animals applicable applied approaches appropriate approximate averaging better blocks blood blurred bolus bootstrap brain captured cerebral combinations completely component components contrast contribute correlation course courses criterion datasets delivered described detect detecting detection detects deviation diameter difficult digits disagreement displacement display distal driven effective estimation evaluate even exceeded exhibit explained filtered filtering findings focal framework functional future gift greater hypothesis independent individual injected length linear location maps model monkeys motion noise outperforms pass patterns performance positive predicted prepared preprocessed preprocessing previous principal prior profiles real reasonable related reports resolution response resting resultant runs saline scaled scanner science scores selected selection separated series session sessions setting seven several shot simulated skin source stability stable steps stimulation stimulus studies successfully suggests tang temporal terms toolbox towards true underlying upon utilized variance varying vertical volumes weak wise worse yield yielded yields