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Abstract #2068

High Spatial and Temporal Resolution FcMRI with BOLD Selectivity Using Multiecho Simultaneous Multislice EPI

Valur Olafsson1, Jia Guo1, Chi Wah Wong1, Prantik Kundu2, Souheil Inati3, Wen-Ming Luh3, Vinai Roopchansingh3, Noah Brenowitz2, Peter Bandettini2, 3, Eric Wong1, Thomas Liu1

1UCSD Center for Functional MRI, La Jolla, CA, United States; 2Section on Functional Imaging Methods, NIMH, Bethesda, MD, United States; 3Functional MRI Facility, NIMH, Bethesda, MD, United States

Motion and physiological noise confounds are key factors that limit the sensitivity of resting-state functional connectivity MRI (fcMRI) measures. The acquisition of multiple echoes has been shown to be effective for automatically identifying and removing these confounds. However, the acquisition of multiple echoes requires additional readout time and leads to a decrease in temporal resolution. To address this issue, we have used a simultaneous multislice excitation strategy to compensate for the extra readout time and achieve whole brain coverage with 3 echoes, 2 mm isotropic resolution, and a TR of 2 seconds.

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Keywords

acceleration achievable achieve achieved acquisition acquisitions additional advantage applied automated blipped bold bottom brain capabilities cerebral characterizing closed coil collected combined comparable components computed concatenated confounds conjugate connectivity contributions correction correlated correlation cortex coverage dataset decomposed decrease degrees differentiate duration echoes emerged enable enables every examine excitation extra eyes fast filter filtering findings fluid fold freedom frequency function functional gained glover goodness gradient greater human identification identify improves independent indicating integration isotropic iterative largely leads limiting local maintain maps matrix measures metric minute model motion need noise optimally outweighs partial partially pass patterns penalty performance physiological posse post posterior presence prior process processing readout receive recent recomputed reconstruction reduced regressing regularization regularized removal removed require required resolution resting retrospective robust roughness section seed selectivity sensitivities sensitivity series simultaneous slice slices smith smoothness space spatial spatially specificity spinal strategy subject suggest system temporal term threshold thresholded tissue trajectory unaffected volume volumes whole