Meeting Banner
Abstract #2030

Observation of Anomalous Perfusion Effects in the Rat Liver Using Temporal Diffusion Spectroscopy

Sabrina Doblas1, Philippe Garteiser1, Mathilde Wagner, 12, Valrie Vilgrain, 12, Bernard E. Van Beers, 12, Ralph Sinkus1

1U773-CRB3, INSERM, Paris, France; 2Radiology Department, Beaujon University Hospital, Clichy, France

The oscillating-gradient spin-echo (OGSE) technique is based on the replacement of classical motion-encoding gradients by oscillating gradients, to obtain DWI experiments with short evolution times and corresponding spatial scales in the order of the micron. This lead to higher ADC compared with ADC determined using a classical EPI-DWI acquisition with relatively long evolution time. in vivo experiments were conducted in rats presenting different hepatic lesions, and showed the interest of using OGSE to gather a new dimension of information on tumor microenvironment and vasculature.

Abstract PDF Poster PDF

Keywords

according acquiring addition aims allowed allows anesthetized animal animals anomalous applied approximately assess beers better biomedicine brains cancer cells cellular characterization classical coefficients conducted considered contrast control determined diameter dictates diffusion dimension diseased displacement displacements distribution dynamic early encoding enough envisaged evolution feasibility fibrosis fixed focuses frequency functional gating good gore grade gradient gradients guarantying healthy hepatic hospital identical in vivo induced induction injection injections insert instance larger leading lesion lesions limitations liver lobe long lost material matrix measure metastases metastasis micron molecules morphological motion nature need novel objects observable observation obstacles optimal oscillating oscillation parsons pathological perfusion phenomenon position potential predominant probe probed processes prone pronounced proposed quality quantify radiology rats related relatively rendering replacing resp restricts scale scales sensitive separating short shortened since slices spatial spectroscopy spin strength structural sufficient suggest system technical temporal theoretical therapy tissue tissues treatment tumor twice understand usually vitro water week weeks whether