Meeting Banner
Abstract #2026

Investigation of Physiological Parameters for Pulsed ASL in Calf Muscles.

Hou-Jen Chen1, 2, Graham A. Wright1, 2

1Sunnybrook Research Institute, Toronto, Ontario, Canada; 2Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

This work presented an optimization of Arterial Spin Labeling for peripheral limbs. The arterial and perfusion responses after exercise during temporary ischemia were characterized. Perfusion was also measured with different post-labeling delays in a paradigm where the hyperemia was prolonged. The blood velocity was used to estimate the ideal sequence repetition time and spatial extent of labeling. The image samples at different delays were used to estimate transit delay. Quantification of perfusion and the sensitivity to peripheral hyperemia can be improved by physiological optimization based on the data.

Keywords

accurate acquisition addition allowed apply approaches arterial arteries asked assessment averaging axial better blood bolus bone calf causing clear coil compartment continuous control critical cuff deep deflated delay detailed discomfort distinct drastically duration efficiency efficient either enhancement error every exclude exercise experiment extent fair fast fitting flow goal graham hand healthy hyperemic ideal identify inch included inflated inversion inverted involvement labeled labeling lateral lead least magnetization mainly matrix measure minimize minute minutes muscle muscles observe optimal optimization pairs peak peaks perfusion perhaps period periods peripheral perturbation perturbations physiological plantar post posterior previous profiles protocol providing pulse pulsed quantification quantify reception recognized reduces regional release repeated repetition repetitions reports respectively response responses rest roughly sample saturation scanner selectively sensitivity separate shot skeletal slab slice slow spatial spin square stage started static steady studies subject subsequent substantial suppression tail temporal tibial tissue tissues together transit twice upstream variation velocities velocity views volunteers young