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Abstract #1928

Structural Connectivity of the Left Anterior Temporal Lobe: A Diffusion Tensor Imaging Study

Nico D. Papinutto1, 2, Sebastiano Galantucci, 23, Roland G. Henry2, Jorge Jovicich4, Maria Luisa Gorno-Tempini2

1CIMeC, University of Trento, Mattarello , TN, Italy; 2University of California San Francisco, San Francisco, CA, United States; 3Scientific Institute and University Hospital San Raffaele, Milano, MI, Italy; 4CIMeC, University of Trento, Mattarello, TN, Italy

The anterior temporal lobe (ATL) is crucial for higher order language functions, such as semantic memory, and it is involved in behavioral regulation. Evidences of ATL damage are found in many neurological diseases, but little is known about the structural connections of this area with the rest of the brain. In this study, by using DTI on 21 healthy subjects, we explore the architecture of the left ATL connectivity with many ipsilateral regions of the brain (in particular the areas known to have a key role in language) and we segment the ATL based on these connectivity patterns.

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Keywords

acquisition aging analyses angular anisotropy anterior applied architecture atlas axial basically behavioral belonging besides blue brain channel classified computed connected connection connections connectivity corrected cortex cortical created crucial damage defined described diffusion diseases distortions distribution distributions dorsal eddy equipped estimation evidenced evidences existence explore extraction finally flirt fractional frontal functions fusiform gradient gradients gray green healthy hemisphere henry hereafter highest humans included inferior insights institute inverted involved involvement known language lateral least library light linear little lobe long longitudinal mainly many maria masks memory middle motion native normalized occipital offer oxford parallel parietal part particular passes passing pattern patterns pink pole posterior previously price probabilistic probability receive recruited regarding regulation related reported resolution rest role scanner scientific seed segment segmentation selected semantic separate space spaces step streamlines structural structures subject subjects superior system target targets temporal tensor thresholded tool tools tract tracts transformations transformed trio underlying various ventral violet warren yellow