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Abstract #1927

The Medial Forebrain Bundle - A Forgotten Structure in the Human Brain Identified with Statistical Fiber Mapping

Burkhard Mdler1, Thomas E. Schlpfer2, 3, Jaak Panksepp4, Volker A. Coenen1

1Neurosurgery, University Bonn, Bonn, NRW, Germany; 2Psychiatry and Psychotherapy, University Bonn, Bonn, NRW, Germany; 3Psychiatry and Mental Health , Johns Hopkins University, Baltimore, MD, United States; 4Comparative Anatomy, Physiology and Pharmacology, Washington State University - College of Veterinary Medicine, Pullmann, WA, United States

The neuroanatomy of the MFB shows remarkable differences between rodents and humans. In rodents the MFB is large but a compact heterogeneous pathway that is a massive connection highway for integrating lower and higher brain functions whereas in humans the MFB depicts as a truly bipartite structure. It is evident that the MFB contains the major brain system that is responsible for a variety of drug addictions. Thus, one could imagine that inadvertently caused stimulation of the MFB during STN DBS-stimulation could be addictive but also the possibility of localized DBS of the slMFB may skirt some of the other brain processes that produce addiction.

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Keywords

able access acquisition addiction administration affective anatomy anterior appreciated array ascending atlas atlases axial bipartite brain branch bundle caused cerebellum certain circuitry coil commonly compact comparative comprised compute connection connects constitutes continuity deep depicts depression derived descending deterministic diffusion direct disorders distinct done drug elastic evidently exhibits extend fiber fibers form formation full functions gadolinium gold gradient green heterogeneous highway human humans hypothalamus identification identified identify imagine individual intermingles isotropic johns lateral learning liking localized located loosely mainly major mapping maps masking massive matrix medial neurons nevertheless nuclei nucleus orientation oxford parallels part parts pathway pathways pharmacology physiology pons prepared press probabilistic probability processes protocol protocols psychiatry psychotherapy radiation registration repertoire resolution responsible reticular reward rewards robustly rodent rodents sense sensitivity separation side slice slices space spin starts statistical stimulation structural structure structures studied subjects subsequent superior system tracking tract truly trunk upper variety ventral visage visualization wall wanting warping whole