Meeting Banner
Abstract #1921

Validation of a Template-Based Approach for Quantitative Tract-Specific Analysis of Diffusion Spectrum Imaging Data

Chieh-En Tseng1, Yung-Chin Hsu2, Yu-Chun Lo3, Wen-Yih Isaac Tseng3, 4

1Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 4Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

We proposed an automatic tract-specific analysis based on a diffusion spectrum imaging (DSI) template. This template-based approach entails transformation of native DSI data to the template, and performs tract-specific analysis on the transformed DSI data. The approach inevitably blurs out the data and may lead to errors in quantitative analysis. To investigate this question, the template-based approach was compared to a native-space approach. Fifteen subjects were analyzed. The results showed that mean generalized fractional anisotropy (GFA) was lower in the template-based approach, but the two approaches showed strong correlation. The results support the use of template-based approach in tract-specific analysis.

Abstract PDF Poster PDF

Keywords

accuracy allows although analyze anisotropy approaches automatic balanced biomedical biomedicine blurs brain bundle bundles bypasses called channel chin coil college connectivity consuming contrast coordinates correlation dataset deformation determined diffusion encoding engineering entails errors establish established evaluate evidence existing expected fiber fields fifteen fractional generalized gradients grid head hospital individual inevitably institute lead local maintains major manual mapping materials matrix medical medicine metric ming namely national native onto optoelectronic overcomes path pathways planar pool poor potentially problems projected prone propose quantitative radiological randomly recently refocused reproducibility requires resolution resolved sampled samples sciences selected selection sensitivity slice smoothing space spatial spectrum streamline structural subjectivity subjects substantial supportive system tailed targeted template throughput totally tracked tracking tract tracts transformation transformed trend trio twice units useful validation vector white yang