Meeting Banner
Abstract #1918

Within Subject Reproducibility and Between Subject Variability of Super-Resolution Track-Weighted Imaging

Lisa Willats1, David Raffelt1, Robert Elton Smith1, 2, Jacques-Donald Tournier1, 2, Alan Connelly1, 2, Fernando Calamante1, 2

1Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia; 2Department of Medicine, University of Melbourne, Victoria, Australia

Recently several novel image contrasts derived from whole-brain fibre tracking-data (tractograms) have been introduced. The novel contrasts of these track-weighted imaging (TWI) methods may provide important information for clinical studies. However, before they can be used reliably to generate quantitative measures, it is important to characterise the within-subject intra-session and inter-session reproducibility, and between-subject variability. In this work we investigate the within-subject reproducibility (both intra-session and inter-session), and between-subject variability of TWI for a number of different contrasts across multiple subjects.

Keywords

acquisition although anisotropy apparent background better black blue bold bottom brain bundle bundles carried cells coefficient computed concordance considered considering consistency constrained contrast contrasts corpus correction correlation cortical created curves dashed dataset datasets date deconvolution denoted density depends detail diffusion distribution dotted encapsulate errors exacerbated expect extent field fractional generate generated gives greater greatest grid healthy house illustrates imperfect important included index indicates institute institutes intensity inter intra intraclass introduced investigate isotropic largest lowest major maps measures median million modulated motion native note novel passing percentile poor primarily probabilistic proceeding processing properties proportion proportionally quantitative recently regional registered registration reliably repositioning reproducibility resolution resolutions response rich robust sensitivity session several similarity similarly since smith software solid sophisticated space spatial spherical statistical statistics step steps still streamline streamlines studies subject subjects subset super table template third track tracking tracks trio uniform unity unsurprisingly utility variability variance variances variation weightings whereas widths windowing