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Abstract #1873

Functional Diffusion Maps (FDMs) in Glioblastoma Treated with Dendritic Cell Therapy.

Robert J. Harris1, 2, Robert M. Prins3, Whitney B. Pope1, Timothy M. Cloughesy4, Linda M. Liau3, Benjamin M. Ellingson1, 2

1Radiological Sciences, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, United States; 2Biomedical Physics, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, United States; 3Neurosurgery, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, United States; 4Neurology, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, United States

Immunogenic dendritic cells have recently been studied as a novel therapy for human brain tumors. In this study, we examine MRI anatomical and diffusion data for ten patients before and after dendritic cell treatment. Functional diffusion maps were calculated using serial diffusion images. One patient with a clear partial response showed a decrease in the volume of decreasing ADC voxels coupled with an increase in increasing ADC voxels during the time following treatment, while two patients with progressive disease showed opposite trends. This suggests that a steadily decreasing volume of decreased ADC following therapy is associated with a favorable response.

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