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Abstract #1872

Evaluation of Pre-Defined Atlas Based ROIs for the Analysis of DTI Data in Normal Brain Development.

Amritha Nayak1, 2, Lindsay Walker1, 2, Carlo Pierpaoli, The Brain Development Cooperative Group3

1STBB-PPITS, National Instritutes of Health, NICHD, Bethesda, MD, United States; 2Center for Neuroscience and Regenerative Medicine (CNRM), Bethesda, MD, United States; 3www.NIH-PediatricMRI.org

We have evaluated the Atlas based image analysis using Large Deformation Diffeomorphic Metric Mapping (LDDMM) on DTI age specific group average brains that have been created from a large cohort (0-22 yrs) of subjects that were recruited as part of the NIH MRI Study of Normal Brain Development project. Our goal has been to understand the utility of the atlas based method in accurately handling and extracting diffusion values that are representative both of the underlying structure and normal development.

Keywords

able addition address adult affected aged agreement anisotropy applied applying aspect assessed atlas attributable available averaging behaviors bias brain brains capture cerebral characteristics component computed contiguous cortex coverage created database days decrease defined deformation deriving development developmental diffusion diffusivity drew effectively enable entire evaluation exaggerated example extract extracted fact feasibility female findings five fractional full function general health healthy heterogeneous homologous human important inaccuracy included inconsistent independent isotropic issue jagged largest limb limitations literature made mapping maps meeting metric metrics much national native originating pages particularly pediatric pipeline placement plotted plus populations positive posterior potential predefined presence previous previously processed producing project prospective puzzling quality radiology reasonable recently regenerative regional registration reported repository representative represents resolution scanned scanner seems sensitization slice snook software spinal spurious structures studies subject subjects successfully supported surrounded systematic template tensor thin tissue tool tortoise trace tract trajectories trajectory trans transformed trend trends various volume walker years