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Abstract #1849

Drug Modulation of ADC and IVIM Parameters in the Native Rat Kidney Measured Using Parallel Imaging with Standard Vendor Coils on a 1.5T Clinical System.

Neil Peter Jerome1, Jessica K R Boult1, Matthew Orton1, David J. Collins1, 2, Simon P. Robinson1, Dow-Mu Koh2

1CRUK-EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

The superior hardware and development of clinical MR imaging systems make them attractive for preclinical studies; limited signal, and thus spatial resolution, for small animal work can in part be overcome by use of parallel imaging with combinations of vendor coils. We demonstrate the use of a clinical 1.5 T system in acquiring diffusion images of normal rat kidney with isotropic resolution 1.5 mm3, and show sensitivity to changes in diffusion and flow parameters obtained from fitting ADC and IVIM diffusion models following administration of hydralazine (systemic vasodilator), furosemide (loop diuretic), and angiotensin II (systemic vasoconstrictor).

Keywords

accurate acknowledge acquisitions action adept administration affected agents anatomic animal apparent appropriate arena array basis biomedical bold bolus butterfly cancer catheter chain challenge changing clarity clear clinical coefficient coil coils complex components considering consistent coronal correlate cortex cortical critical curves decrease decreasing detail differentiation difficult diffusion diffusivity diuretic drug dysfunctional error evaluate excessive expected exponential extremity filtering fitted fitting flow fraction funding greater head health heat heterogeneous highly immediate incoherent indicates infused initial institute insulating intra italic kidney kidneys kingdom larger lateral lead matrix measurable measured median medulla minutes model models modulation nature observations organs package parallel perfusion perhaps peter physiological post prevent prior properties proprietary providing pseudo quality rank rats received regarding required resolution response retain reverse rise scanner scanners secured segmentation sensitivity separate signed significantly similarly software studies subtle suitable supine suppression surrey system systemic table tail temporal term together true tubular unpaired utility vacuum vascular vein vendor whole