Meeting Banner
Abstract #1831

Microstructure of the Marmoset Cerebral Cortex Observed Using High Resolution Diffusion Weighted Imaging

Frank Q. Ye1, David A. Leopold1, Mustafa Irfanoglu2, Carlo Pierpaoli2, Afonso C. Silva3

1NIMH, National Institutes of Health, Bethesda, MD, United States; 2NICHD, National Institutes of Health; 3NINDS, National Institutes of Health

It is known that axons in the cerebral cortex show distinct organization patterns, which in principle can be mapped by diffusion MRI. Up to now, diffusion imaging has not yet proved its value in study the microstructure of cortical gray matter. In this study, q-ball diffusion data of high spatial resolution and high SNR were acquired from a fixed marmoset brain. Interesting diffusion contrasts are observed in various cortical regions that could potentially be used to delineate cortical layers or to parcellate cortical structures.

Keywords

accompanying achieve acquisition allows among angular anisotropic anisotropy areal artifacts attempts avoid basis better birdcage brain cell cerebral challenge characterization characterized coil collected column combined combining components concise connectivity contains cook coronal cortex cortical decomposition deliver described diameter differ difficulties diffusion dimensional distribution dominating double easy echoes eddy encoded example fact fewer fibers field fixed focusing form formalin frank free fully function functions ghosting gray hampered handle harmonic harmonics health healthy highest highlight important in vivo inherently institutes inverted isotropic laboratory laminated layers long lowest magnitude maps marmoset matrix measuring middle mode model models much national normalized often orientation overcome partial particularly patterning peak peaks pediatric placed poorly popular preprocessed profile properties pushed quality radial reconstruct requires resolution running scale scanned scanner search searched segmented segments served simple smaller space spatial spherical spin stains statistics strength summarize taken tangential temporal tensor term third together toolkit tortoise understand understood upon usage utilize volume white