Meeting Banner
Abstract #1830

Effect of Cell Membrane Water Permeability on Diffusion-Weighted MR Signal: A Study Using Expression-Controlled Aquaporin4 Cells

Takayuki Obata1, Jeff Kershaw2, Daigo Kuroiwa1, Sayaka Shibata2, Abe Yoichiro3, Masato Yasui3, Ichio Aoki2

1Center for Charged Particle Therapy, National Institute of Radiological Sciences (NIRS), Chiba, Japan; 2Molecular Imaging Center, NIRS; 3Department of Pharmacology, Keio University, Tokyo, Japan

We performed multi-b-value and multi-diffusion-time DWI on AQP4-nonexpressed (noAQ) and AQP4-expressed (AQ) cells to investigate the effect that CMP has on diffusion-weighted magnetic resonance signal. Significant signal differences between the noAQ and AQ cells were observed only at high b-values. Diffusion-time dependent ADC changes were also observed, but there were no significant differences between the noAQ and AQ cell samples.

Abstract PDF Poster PDF

Keywords

absence affect although amplitude animal assumption attenuation brain cancer cell cells cellular channel charged clear coefficients compartmental compartments consistent contrast contribution controlled curve dependent depth diagnosing diffusion diseases dominant dominated effective established exchange experiment exponential expressed expression extra extracellular facilitate fast fitting fractions full gantry gradient important includes increasing indicate indicated infarction institute investigate japan known located membrane model molecular molecules national oscillating parsons particle perhaps permeability pharmacology plays pulsed quantitative radiological reflect relating reliable remains respect restricted restriction role samples sciences slow space spin steps still suggests suspended system therapy tissue types understood volume water