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Abstract #1796

Longitudinal Cerebral Metabolic Alternations in a Novel Macaque Model of Neuro-AIDS

Chunxia Li1, Xiaodong Zhang1, 2, Amelia Komery2, Yingxia Li3, Hui Mao4, Francis J Novembre5, James G. Herndon2

1Yerkes Imaging Center,Yerkes National Primate Research Center , Emory University, Atlanta, GA, United States; 2Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 3Yerkes Imaging Center,Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 4Department of Radiology, Emory University, Atlanta, GA, United States; 5Divisions of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

In this study, a novel macaque model of neuro-AIDS was employed to investigate the longitudinal cerebral metabolite alternation in asymptomatic patients with in vivo MRS at 3T. The results demonstrated that NAA was reduced significantly in the acute phase and Glx was reduced significantly in both acute and chronic phases after the SIV inoculation. The progressive alternations in NAA and Glx correlated significantly with the CD8 T cell %.

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