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Abstract #1763

Prospective Evaluation of Liver Steatosis Comparing Stereological Point-Counting Biopsy Analysis and 1H MRS

Mikael Fredrik Forsgren1, 2, Mattias Ekstedt3, Olof Dahlqvist Leinhard1, 2, Oscar Andregrd, Nils Dahlstrm, 24, Johan Kihlberg, 24, Stergios Kechagias5, 6, Sven Almer6, 7, rjan Smedby, 24, Peter Lundberg1, 2

1Depts of Radiation Physics, Linkping University and Radiation Physics, UHL County Council of Ostergotland, Linkping, Sweden; 2Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden; 3Depts of Clinical and Experimental Medicine (IKE), Faculty of Health Sciences, Gastroenterology and Hepatology unit, Divison of Inlammation Medicine, Linkping University, Linkping, Sweden; 4Depts of Medical and Health Sciences (IMH), Division of Radiological Sciences, Linkping University, Linkping, Sweden; 5Depts of Medical and Health Sciences (IMH), Division of Cardiovascular Medicine, Linkping University, Linkping, Sweden; 6Depts of Endocrinology and Gastroenterology, UHL County Council of Ostergotland, Linkping, Sweden; 7Depts of Clinical and Experimental Medicine (IKE), Divison of Gastroenterology and Hepatology, Linkping University, Linkping, Sweden

Measuring the degree of liver steatosis is often important for treatment and prognosis in both a clinical and research context. The quantitative stereological point-counting analysis of biopsies has been shown to have high reproducibility, 1H MRS is a viable non-invasive method for liver fat content estimation. In this prospective study we have shown a good correlation between quantitative 1H MRS and stereological point-counting analysis of biopsies (Spearman rho = 0.90).

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Keywords

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