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Abstract #1762

Cholesterol Detection in Adipose Tissue by Natural Abundance in vivo 13C MRS at 7T

Xing Chen1, Peter Boesiger1, Anke Henning1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Adipose tissue is a major site of cholesterol storage. A variety of nutritional and metabolic alteration may influence the adipose tissue cholesterol level which has been studied in rats by chemical analysis. Localized natural abundance 13C MRS has been shown to be a powerful noninvasive technique for the study of lipids in vivo and has been applied to study the major classes of fatty acids. In this work, detection of cholesterol is reported for the first time noninvasively in human calf adipose tissue by 13C MRS at 7T, with J-refocused 1H PRESS localized DEPT sequence combined with broadband decoupling.

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Keywords

abnormal abundance accordance acid acids addition adipose adjacent agreement alteration angel animal applied assigned assignments atoms averaging barely biochemistry biomedical black blue body broadband brown calf carbon cardiovascular chem chemical cholesterol classes coil combined completely component components consistently constants coupling couplings covering decoupling dept detect detecting detection dietary disease double dual eight engineering enhancement envelop established extremity fatty five frequency green healthy henning human in vivo index influence inserted institute interaction library like limit lipid lipids literature load localization localized long major marked materials membranes metabolic metabolism middle might mono natural noninvasive nutritional obvious offset optimized part partial peak peaks peter polarization polyunsaturated potential powerful press previous probably proposed pulse pulses quadrature rats refer refocused reported respectively roles saturated scalar sensitive site slightly spectra spectroscopy stem storage strongly structural studied subject subjects system table tentatively timing tissue tissues trans transfer tuned twice ubiquitous unit unsaturated variety vital volume waltz whole yellow zoomed