Distinguishing Sensitive and Resistant Early Therapy Response of Pancreatic Tumor Xenografts Using 13C-MRS of Hyperpolarized Pyruvate

Keywords

acid acquisition activity administered administration advancement animals apparent assessing background bearing biochemical bring cancer cancers catheter causes cell chosen citric coefficient coil containing control controls conversion cycle daily dang days decreased detect detecting determine diffusion disease dissolution dissolved distinguishing doses drug dual dynamic early efficacy endogenous enhancement evaluated excised experimental fatty feature flux fold fresh hospital hour human importantly in vivo informs inhibition inhibits initiated injection institute intravenous johns jugular label labeled lactate marker media medicine metabolic metabolism metabolize mice modalities molecule monitor much nature noninvasive nontoxic nuclear nude observation pancreatic pathway pathways patients peaks permitted physiological polarization polarizer post potential preferentially probes progression proliferation radical real received recent reduced reported resistant respectively response reviews sample scanner school sensitive seven significantly sooner specimens spectra spectroscopy staining subcutaneous substances substrates suggesting synthesis technological therapy tissue tissues transplanted treated treatment tumor tumors tuned untreated uptake utilizing validated vein volume water week whereas