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Abstract #1682

Detection of Radiation Response of Prostate Cancer in TRAMP with Hyperpolarized 13C MRSI

Lasitha Senadheera1, Dirk Mayer2, 3, Sonal Josan2, 3, Yi-Fen Yen4, Moses Darpolor3, Jae Mo Park3, Ralph E. Hurd4, Richard Luong5, Lei Xing1, Daniel M. Spielman3

1Radiation Oncology, Stanford University, Stanford, CA, United States; 2Neuroscience Program, SRI International, Menlo Park, CA, United States; 3Radiology, Stanford University, Stanford, CA, United States; 4Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Comparative Medicine, Stanford University, Stanford, CA, United States

Radiation-induced metabolic response of TRAMP prostate tumor was investigated with 13C MRSI of hyperpolarized [1-13C]Pyruvate. The pyruvate metabolism in the tumors of two groups of mice, x-ray treated and untreated, was assessed in terms of Lactate/Pyruvate ratio. The Lactate/Pyruvate ratio was uncorrelated with the tumor size but was significantly (P < 0.05) lower in the treated group than the untreated. Our preliminary data suggest the feasibility of using 13C MRSI for detecting therapeutic response of prostate cancer to radiation in TRAMP mice.

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