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Abstract #1601

Simulation of Percutaneous Coronary Intervention: MRI and MDCT Assessment of Coronary Microemboli

Maythem Saeed1, Loi Do1, Steven W. Hetts1, Mark Wilson1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States

The purpose of this transitional study was to determine threshold microemboli volume that causes visible microinfarct on MRI and MDCT. Cardiac injury biomarkers and histochemical staining were used to confirm the presence of myocardial injury. Pigs (n=18) received either 16mm3 or 32mm3 volumes of 40-120μm diameter microemboli. Three days after intervention contrast enhanced MDCT and MRI were performed. A threshold method was used to measure microinfarct on MRI/MDCT. Creatine-kinase MB, troponin I and triphenyltetrazolium chloride stain were used to confirmed myocardial injury. MRI and MDCT may be useful in evaluating the effectiveness of new therapies and future distal filtration devices.

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Keywords

achieving acute administration angioplasty animal animals approaches arteries artery assessment automatic autopsy beyond biomedical biosphere blood branch brick calculations cardiac catheter cause caused causes chase chloride confirm confirmed contrast coronary days delayed delivered delivering determination determine devices diagnostic diagonal diameter diameters difficult directional dislodged distal effectiveness eighteen either elevation enhanced enhancement equation erosion established evaluating extraction failed filtration flow furthermore future greater guidance heart heterogeneous histochemical hypothesis infarct injected injector injury insufficient interchangeably intervention interventions laboratory larger laser lodged mark mass measure media modalities myocardial myocardium necrosis necrotic obstruction occurs pathologists patients pattern percutaneous pigs placed plaque power presence produce produced produces radiology radius randomized rapid reasons receive received reduction reproducible respectively retrieved rupture saline satisfactory selected selectively semi significantly simulation slice speckled spontaneous stain staining studied subtended sufficient terms territory therapies threshold transitional ultrasound unlike unstained useful vessels viability viable visible visualization visualize visualizing volume volumes